At its current O-level standard, in accordance with the national curriculum prescribed by the Ugandan Ministry of Education and Sports, the school offers both science and art subjects. The following subjects are taught at St. Francis of Assisi: Mathematics, English language, English literature, Physics, Chemistry, Biology, Agriculture, Geography, History, CRE, Swahili, ICT, Art, and Entrepreneurship. These subjects are taught by qualified teachers who are certified by the Ministry of Education and Sports. Students are taught not to memorise content but to think through it and be able to apply the knowledge acquired.