St. Francis of Assisi High School offers a wide range of co-curricular activities aimed at growing the range of talents of students, encouraging them to become valuable in other spheres of life, beyond intellectual competence.

Students join a variety of clubs such as Debating, Music Dance and Drama (MDD), Environmental Protection, Young Christian Students (YCS), and Patriotism Club. Some clubs are meant to be just for fun and offer a great way to grow socially and make new friends, while others can be a great way to develop and expand leadership skills. Every student is a member of one or two of the existing clubs.

Besides clubs, students engage in different sports which include volley ball, (which both boys and girls seem to enjoy), netball, and football. Students also enjoy indoor games.